Doves, Diplomats, and Diabetes

Doves, Diplomats, and Diabetes

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Darwinian medicine looks at the ecological and evolutionary roots of disease. A disease is an interaction between a genome and its biotic or abiotic environment and therefore a disease is essentially an ecological process. Good understanding of ecology and a Darwinian way of thinking can give us novel and useful perspectives on health and disease. If we understand the disease process better, we can certainly prevent, control as well as treat diseases in a better way. Although the thought that the origins of obesity and type 2 diabetes (T2D) might lie in our hunter gatherer adaptations is not new, research over the last decade makes us rethink many of the classical concepts. Brain and behavior is increasingly being recognized as central to all the endocrine, metabolic and immunological changes that earmark type 2 diabetes and other metabolic syndrome disorders. A major change in paradigm appears to be on the horizon and the proposed book intends to speed up the paradigm shift by raising important questions, pointing out flaws and inadequacies in the prevalent paradigm and stimulating radical rethinking which would redirect and refine the line of research as well as bring some fundamental changes in drug discovery and clinical practice. a€‹However there is much ambiguity about whether obesity causes insulin resistance or insulin resistance leads to obesity. ... a a€œdiabetic tendencya€ (the concept of insulin resistance was not there when Neel wrote this paper) was responsible for obesity. ... In India, for example, it is just too common to find normal weight or even lean and thin type 2 diabetics. ... about the role of genes in obesity and diabetes to realize that after the genome data became available, the genetics argument hasanbsp;...

Title:Doves, Diplomats, and Diabetes
Author: Milind Watve
Publisher:Springer Science & Business Media - 2012-08-30

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