Fundamentals of Chromatin

Fundamentals of Chromatin

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a€‹a€‹a€‹a€‹a€‹a€‹a€‹a€‹a€‹a€‹a€‹a€‹a€‹While there has been an increasing number of books on various aspects of epigenetics, there has been a gap over the years in books that provide a comprehensive understanding of the fundamentals of chromatin. a€‹Chromatin is the combination of DNA and proteins that make up the genetic material of chromosomes. Its primary function is to package DNA to fit into the cell, to strengthen the DNA to prevent damage, to allow mitosis and meiosis, and to control the expression of genes and DNA replication. The audience for this book is mainly newly established scientists a€‹and graduate students. Rather than going into the more specific areas of recent research on chromatin the chapters in this book give a strong, updated groundwork about the topic. Some the fundamentals that this book will cover include the structure of chromatin and biochemistry and the enzyme complexes that manage it.HR and NHEJ both repair breaks in the phosphodiester backbone that occur on both strands of DNA. ... used to a€œsticka€ the DNA ends back together, whereas the more accurate HR pathway a€œpatchesa€ the DNA break using a homologous sequence as the template. The mechanism for repair of DNA damage in the context of chromatin has been termed the a€œAccess, Repair, Restorea€ model ( Smerdon 1991).

Title:Fundamentals of Chromatin
Author: Jerry L. Workman, Susan M. Abmayr
Publisher:Springer Science & Business Media - 2013-12-04

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