Molecularly Targeted Therapy for Childhood Cancer

Molecularly Targeted Therapy for Childhood Cancer

4.11 - 1251 ratings - Source

Each chapter will focus on the known molecular characteristics of specific childhood cancers, focusing on how the molecular a€˜driversa€™ can be exploited from a therapeutic standpoint with currently available targeted agents. Where applicable, integration of targeted therapies with conventional cytotoxic agents will be considered. This volume will provide a comprehensive summary of molecular characteristics of childhood cancers, and how the changes involved in transformation provide us with opportunities for developing relatively less toxic, but curative, therapies.... the initial discovery of MLL as the gene disrupted by the translocations approximately 18 years ago (Ziemin-van der Poel et al. ... diseases that originate in utero from DNA damage to MLL that results in the formation of the translocations (Ford et al. ... 2002) that controls epigenetic modifications of nucleosomes and histones and maintains HOX expression (Hess 2004). ... MLL translocations disrupt a breakpoint cluster region and fuse 5Ac MLL with the 3Ac portion of the partner gene, anbsp;...

Title:Molecularly Targeted Therapy for Childhood Cancer
Author: Peter J. Houghton, Robert J. Arceci
Publisher:Springer Science & Business Media - 2010-09-10

You must register with us as either a Registered User before you can Download this Book. You'll be greeted by a simple sign-up page.

Once you have finished the sign-up process, you will be redirected to your download Book page.

How it works:
  • 1. Register a free 1 month Trial Account.
  • 2. Download as many books as you like (Personal use)
  • 3. Cancel the membership at any time if not satisfied.

Click button below to register and download Ebook
Privacy Policy | Contact | DMCA