The role of arginase in endothelial dysfunction

The role of arginase in endothelial dysfunction

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In recent years, an increasing number of manuscripts have been published addressing the deleterious role of arginase in endothelial dysfunction. ROS have been shown to play a crucial role in arginase activation, which in turn leads to eNOS dysfunction.Our studies in rodent models of diabetes have shown that impairment of retinal endothelialdependent vasodilation is ... the Care and Use of Laboratory Animals and were approved by the institutional animal care and use committee (Animal Welfare Assurance no. ... Mice with glucose level over 350 mg/dl as determined by a blood glucose meter were considered diabetic. ... Immunoreactive proteins were detected using the enhanced chemiluminescence (ECL) system (GE Healthcareanbsp;...

Title:The role of arginase in endothelial dysfunction
Author: Rudolf Lucas
Publisher:Frontiers Media SA - 2015-04-14

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